Assays - Piracetam

Rapid method for the sensitive determination of Piracetam in plasma by high-performance liquid chromatography

Author: H.J. Mascher, C. Kikuta
Publisher: J. Pharm. Biomed. Analysis 7 (1989), 913-916

Piracetam (2-oxo-1-pyrrolidineacetamide) is a CNS-active substance, which was developed from GABA, an endogen active neurotransmitter substance. Piracetam influences interhemispherical exchange and protects the polyribosomal organism against oxygen-deficit states.
This paper describes a new and reliable HPLC method for the analysis of Piracetam, especially applicable to routine work. The analyses are performed by direct injection of plasma samples after deproteinization and employs UV-detection at 200 nm.