Assays - Cinnarizine

Rapid high-performance liquid chromatographic assay of Cinnarizine in human plasma

Author: V. Nitsche, H.J. Mascher
Publisher: J. Chromatogr. 227 (1982), 521-525

Cinnarizine belongs to the category of antihistamines, more exactly to the sub-category of H1 receptor blockers. It is used in the treatment of cerebral and peripheral circulatory disturbances. Clinical experience of the use of cinnarizine goes back over a period of more than ten years. There is, however, little documentary material relating to pharmacokinetic studies and only a few publications have appeared on methods for cinnarizine assay in biological fluids. The present study describes a method of cinnarizine assay in serum or plasma employing high-performance liquid chromatography. The analysis can be carried out rapidly, it produces accurate results and it is thus especially suitable for routine examinations such as are involved in pharmacokinetic studies.