Assays - Acyclovir2

Pharmacokinetics and Bioavailability of Different Formulations of Aciclovir

Author: H. Vergin, H.J. Mascher, R. Metz
Publisher: Drug Research, 45 (1995), 508 - 515

The pharmacokinetics and bioavailability of aciclovir (CAS 59277-89-3) were examined after administration of newly developed 200 mg and 400 mg tablets. Two studies, each with 24 subjects of either sex, were performed. In the three-way study I, two different tablets containing 200 mg of aciclovir (test and reference products) and a short infusion of 250 mg aciclovir were compared. In the two-way study II, the bioequivalence of a newly developed 400 mg aciclovir tablet was tested against a standard product.