Assays - 5-Fluorouracil

Treatment of Advanced Colorectal Canceer With Folinic Acid and 5-Fluorouracil in Combination with Cisplatinum

Author: P. Sagaster, R. Essl, G. Teich, E. Fritz, M. Wasilewski, H. Umek, E. Dünser, H. Mascher, M. Micksche
Publisher: Eur. J. Cancer, 30A (1994), 1250 - 1254

51 patients with metastatic colorectal cancer (stabe Dukes D) were treated with intravenous (i.v.) infusion on days 1, 3, 5, 8, and 16 with folinic acid (200 mg/m²) and 5-fluorouracil (600 mg/m²), and on days 1, 8, and 16 with cisplatinum (25 mg/m² i.v.); cycles were repeated every 4 weeks. All 51 patients were evaluable for toxicity and response criteria. 26 patients had objective responses (3 complete responses, 5.9 %; 23 partial responses, 45.1 %), relative risk 51 % (95 % confidence intervals 36.7 - 65.0 %). Response duration ranged from 4 to 28.0 months (median 16.8). Overall median survival of all patients was 14.7 months (range 3.0 - 33.0). Toxicity of WHO grade III, requiring dose reduction, occurred in 9 (18 %) patients. The regimen described here appears to be active, safe and well tolerated for treatment of patients with advanced colorectal cancer.