Assays - 5- and 8-Methoxypsoralen

5-Methoxypsoralen: Bioavailability and Pharmacokinetics

Author: V. Nitsche, H.J. Mascher
Publisher: Arzneim.-Forsch./Drug Res. 32 (1982), 1338-1341

The bioavailability of two galenic formulations of 5-methoxypsoralen (5-MOP) is described. A suspension in soft gelatine capsules was tested against a micronized powder in hard gelatine capsules on six volunteers, both in a dosage of 40 mg. The comparison of the AUC shows a significant better availability of the suspension (p ≤ 0.05). The detection limit of 5-MOP is 2 ng/ml plasma. The described analytical method is accurate and rapid - recovery near 100 % - and is suitable for routine analysis. The pharmacokinetic parameters for 5-MOP are 2.3 for the elimination half-life and 0.344 h-1 for the elimination rate constant.